PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
نویسندگان
چکیده
منابع مشابه
Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1cells.
Oxidant-induced cell injury has been implicated in the pathogenesis of several forms of acute renal failure. The present studies examined whether activation of poly(ADP-ribose)polymerase (PARP) by oxidant-induced DNA damage contributes to oxidant injury of renal epithelial cells. H2O2exposure resulted in an increase in PARP activity and decreases in cell ATP and NAD content. These changes were ...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2010
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.12.161